p75 Neurotrophin Receptor Regulates Energy Balance in Obesity
Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis.Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).Despite no changes in food intake, p75NTR-null Power Cord Inlet mice were protected from HFD-induced obesity and r